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Showing posts with label drug. Show all posts
Showing posts with label drug. Show all posts

Steroid Articles And Information And Their Side Effects Shrenksonlinepharma

Contrary to what many would expect, this compound is actually only a weak agonist of the androgen receptor (AR), with poor binding. It follows, then, that its value must mostly come from non-AR-mediated effects. It is therefore a Class II steroid. Since it is not very effective in activating ARs, it should be stacked with a Class I steroid that is effective in

this regard, such as Primobolan, Deca Durabolin, or trenbolone acetate. There is no point in stacking it with Anadrol
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Anabolic Steroids Use

In quite a few illnesses, medical practitioners prescribe anabolic steroids. Use of it is however suggested with caution since the drug is known to show harmful side effects. Ironically, anabolic steroids are used more for non-medical reasons than otherwise, and this has been so ever since its utility for performance enhancement has become widely known among athletes and body-builders. Glossing over what prompts people resorting to anabolic steroids’ use – or is it misuse – here are some main reasons:

Professional athletes in their attempts to over-perform use anabolic steroids. One remembers Canadian sprinter Ben Johnson winning the 1988 Olympic 100-meter dash in Seoul to make a new world record, but later stripped of the title when tests revealed that he partook banned steroid, stanozolol.

Men suffering from behavioral syndromes, believing they look small and insignificant even though they are muscular, use anabolic steroids. Similarly, women with this problem take the drug as they tend to think they are flabby, though in actual they are quite lean and muscular.

It is seen that people who have suffered physical or sexual abuse in the past often take recourse to the drug with the belief that it will make them look stronger and abler thus discouraging any future attacks.

Adolescent youth get a kick out of doing risky things, like driving fast, drinking atrociously and suchlike. They are easily attracted to anabolic steroids’ use.

Are anabolic steroids not used for medicinal purpose? But yes they are. Some examples are:

Helping patients gain weight after a severe illness, injury, or continuing infection. They may also be administered when patients do not gain or maintain normal weight because of unexplained medical reasons.

Treating certain types of anemia and also some kinds of breast cancer in women.

Treating hereditary angioedema that causes swelling of face, arms, legs, throat, windpipe, bowels, or sexual organs.
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Anabolic Steroids In Sport Exercise

In most cases, people use anabolic steroids in sports and exercise. Sportspersons, including athletes, bodybuilders, footballers and others, who put a lot of stake in improved performance on the field, resort to frequent usage of the drug. The same goes for those who wish to build muscles and cut down on body fat, thereby presenting themselves with well-toned physique.

Researchers have found that there is a growing tendency among youth to abuse anabolic steroids. In sport and exercise the phenomenon is known to be happening for quite awhile. But there are cases where apparently well-built persons too use the drug, believing that without it they will look small and insignificant. In medical parlance, it is called muscle dysmorphia, which surprisingly is prevalent in both men and female, though to a lesser degree in latter’s case.

Even as anabolic steroids are known to cause less to grievous harm to health over short to long term of usage, what is equally true is that there are many myths surrounding its supposed ill-effect. One such is that anabolic steroids cause shrinking in penis and testicles. While that is true in short term, over long term the size returns to normalcy soon after exogenous androgen administration is halted. This is one reason why boys at tender age are never suggested to use the drug, for in their case the effect can be quite damaging.

Be that as it may, the fact that the drug can boost muscle size and ability to perform well in exerting games would mean that the use of anabolic steroids in sports and exercise is not going to go away forever. To that extent, the role of agencies to control the abuse of the substances is important.

And indeed that is the reason why the US Anabolic Steroid Control Act of 2004 has been enacted to ban selling and using anabolic steroid and pro-hormone without relevant medical prescription. To what extent the new act is able to check the abuse of anabolic steroids in sport and exercise, while not unnecessarily preventing genuine medical reasons, remains to be seen.
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History Of Anabolic Steroid

Surprising it may seem, but tracing the history of anabolic steroid will reveal that there was prevalence of its use among professional athletes in ancient Greece. In those times, athletes used natural steroidal substances in order to enhance androgenic and anabolic growth in the body.

As the history of anabolic steroid unfolds, one would find that in early 1930s, German scientists discovered the drug in modern pharmaceutical form – albeit accidentally. There was however no immediate interest to pursue research into the drug’s utility.

After a hiatus of nearly 2 decades, the first serious scientific attention to anabolic steroid came upon in 1950s when methandrostenolone or Dianabol was approved by the FDA for use in US in 1958 after it was known to have had promising trials in other countries.

In spite of sporadic trial and use of anabolic steroid from 60s through 80s, doubts remained as to whether it had any real effect. In 1972 a study was done whereby no big difference could be noticed between those who received anabolic steroid injection and those who were given placebo.

Later in 1996, the National Institutes of Health (NIH) decided to examine the effect of the drug by injecting testosterone enanthate in high doses intramuscularly at the rate of 600 mg/week for 10 weeks. The results gave clear indication of increase in muscle mass and decrease in fat mass among those who took the test as against those who took placebo injections.

Meanwhile, the US Congress approved the Anabolic Steroid Control Act of 1990, and accordingly the anabolic steroids are placed into Schedule II of the Controlled Substances Act (CSA).

It is not known how the history of anabolic steroid will trace its route in future. For now, as recently as on January 20, 2005, the CSA has been further amended to make way for Anabolic Steroid Control Act of 2004, vide which both anabolic steroids and prohormones are now controlled substances.
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Information About Steroids By Shrenksonlinepharma

Like methandrostenolone (Dianabol), oxymetholone does not bind well to the androgen receptor (AR), and most of the anabolism it provides is via non-AR-mediated effects. It is therefore a Class II steroid and is best stacked with a Class I steroid. The drug appears to give the same benefits as dianabol. Unlike Dianabol, however, it seems that oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of stanozolol (Winstrol), which is anti-progestagenic. This

progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan, oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast, with testosterone it is a very harsh drug.

Oxymetholone does not convert to estrogen, and thus antiestrogens are not required if no aromatizable AAS are being used. However, in concert with aromatizing drugs, oxymetholone is notorious for worsening “estrogenic” symptoms, possibly by producing progestagenic symptoms which the bodybuilder

confuses as estrogenic, or by altering estrogen metabolism, or by upregulating aromatase.

Compared to what bodybuilders expect of it, the drug is reasonably mild when no aromatizing steroids are present. I consider its potency approximately comparable to Dianabol. It is not unusual for a first time user to do quite well on an oxymetholone-only cycle, but more advanced users will want

to stack with another steroid. Typical use is 50-150 mg/day, which should be divided into several doses per day.

Because oxymetholone is 17-alkylated, it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle, rather than in the last few weeks.

Trivial name Oxymetholone

Systematic name 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-

(hydroxymethylene)-17-methyl-

CAS number 434-07-1

ATC code A14AA05

Merck Index Number 7036

Chemical formula C21H32O3

Molecular weight 332.477 g/mol

Bioavailability 95%

Metabolism Hepatic

Elimination half-life 9 hours

Excretion Urinary: 95%

Pregnancy category X

Routes of administration Oral
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Information About Steroids By Shrenksonlinepharma

Like methandrostenolone (Dianabol), oxymetholone does not bind well to the androgen receptor (AR), and most of the anabolism it provides is via non-AR-mediated effects. It is therefore a Class II steroid and is best stacked with a Class I steroid. The drug appears to give the same benefits as dianabol. Unlike Dianabol, however, it seems that oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of stanozolol (Winstrol), which is anti-progestagenic. This

progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan, oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast, with testosterone it is a very harsh drug.

Oxymetholone does not convert to estrogen, and thus antiestrogens are not required if no aromatizable AAS are being used. However, in concert with aromatizing drugs, oxymetholone is notorious for worsening “estrogenic” symptoms, possibly by producing progestagenic symptoms which the bodybuilder

confuses as estrogenic, or by altering estrogen metabolism, or by upregulating aromatase.

Compared to what bodybuilders expect of it, the drug is reasonably mild when no aromatizing steroids are present. I consider its potency approximately comparable to Dianabol. It is not unusual for a first time user to do quite well on an oxymetholone-only cycle, but more advanced users will want

to stack with another steroid. Typical use is 50-150 mg/day, which should be divided into several doses per day.

Because oxymetholone is 17-alkylated, it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle, rather than in the last few weeks.

Trivial name Oxymetholone

Systematic name 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-

(hydroxymethylene)-17-methyl-

CAS number 434-07-1

ATC code A14AA05

Merck Index Number 7036

Chemical formula C21H32O3

Molecular weight 332.477 g/mol

Bioavailability 95%

Metabolism Hepatic

Elimination half-life 9 hours

Excretion Urinary: 95%

Pregnancy category X

Routes of administration Oral
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