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Showing posts with label steroid. Show all posts
Showing posts with label steroid. Show all posts

Anabolic Androgenic Steroid

What an anabolic androgenic steroid is can be best understood taking the words separately. Anabolic or anabolism refers to that metabolic process in living organisms and cells – such as inside our body – that helps in synthesizing or bringing together smaller molecules to build larger ones. As against catabolism, that does the opposite, anabolism tends to coalesce complex molecules, letting them grow as a whole.

Androgenic stands for that property of a natural or synthetic chemical compound in vertebrates (for example, human beings) that stimulates or controls development and maintenance of masculine characteristics. More commonly, androgen is indicative of developing male sexuality, though testosterone, a well-known androgen, secretes in both the testes of males and the ovaries of females.

Steroid, occurring as it does from sterol like cholesterol, a naturally happening steroid alcohol, is a group of organic compounds including many types of hormones, alkaloids and vitamins.

What follows therefore is that anabolic androgenic steroid is a type of naturally occurring or manmade substance that assists in growth of cells and combining smaller molecules in human body. In other words, anabolic androgenic steroid results in growth of several types of tissues, especially bone and muscle.

Use of anabolic androgenic steroid is popular among people who are interested in enhancement of physical performance – for example athletes and other sportspersons. Some individuals use it because they perceive its use will improve their appearance, in which case it almost becomes an addiction.

In the present time, anabolic androgenic steroid rakes up more controversy than its share, which is mainly on account of abuse of the drug. Many countries have devised stringent measures in attempts to control its use and distribution. However, it has medicinal benefit too.

Classified as Schedule III drugs in accordance with the Controlled Substances Act (U.S. Department of Justice-DEA, 1997), anabolic androgenic steroid is prescribed for treating anemia, osteoporosis, growth stimulation, gonad dysfunction, gynecological disorders, and chronic wasting conditions like cancer and AIDS, among others.
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History Of Anabolic Steroid

Surprising it may seem, but tracing the history of anabolic steroid will reveal that there was prevalence of its use among professional athletes in ancient Greece. In those times, athletes used natural steroidal substances in order to enhance androgenic and anabolic growth in the body.

As the history of anabolic steroid unfolds, one would find that in early 1930s, German scientists discovered the drug in modern pharmaceutical form – albeit accidentally. There was however no immediate interest to pursue research into the drug’s utility.

After a hiatus of nearly 2 decades, the first serious scientific attention to anabolic steroid came upon in 1950s when methandrostenolone or Dianabol was approved by the FDA for use in US in 1958 after it was known to have had promising trials in other countries.

In spite of sporadic trial and use of anabolic steroid from 60s through 80s, doubts remained as to whether it had any real effect. In 1972 a study was done whereby no big difference could be noticed between those who received anabolic steroid injection and those who were given placebo.

Later in 1996, the National Institutes of Health (NIH) decided to examine the effect of the drug by injecting testosterone enanthate in high doses intramuscularly at the rate of 600 mg/week for 10 weeks. The results gave clear indication of increase in muscle mass and decrease in fat mass among those who took the test as against those who took placebo injections.

Meanwhile, the US Congress approved the Anabolic Steroid Control Act of 1990, and accordingly the anabolic steroids are placed into Schedule II of the Controlled Substances Act (CSA).

It is not known how the history of anabolic steroid will trace its route in future. For now, as recently as on January 20, 2005, the CSA has been further amended to make way for Anabolic Steroid Control Act of 2004, vide which both anabolic steroids and prohormones are now controlled substances.
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Information About Steroids By Shrenksonlinepharma

Like methandrostenolone (Dianabol), oxymetholone does not bind well to the androgen receptor (AR), and most of the anabolism it provides is via non-AR-mediated effects. It is therefore a Class II steroid and is best stacked with a Class I steroid. The drug appears to give the same benefits as dianabol. Unlike Dianabol, however, it seems that oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of stanozolol (Winstrol), which is anti-progestagenic. This

progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan, oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast, with testosterone it is a very harsh drug.

Oxymetholone does not convert to estrogen, and thus antiestrogens are not required if no aromatizable AAS are being used. However, in concert with aromatizing drugs, oxymetholone is notorious for worsening “estrogenic” symptoms, possibly by producing progestagenic symptoms which the bodybuilder

confuses as estrogenic, or by altering estrogen metabolism, or by upregulating aromatase.

Compared to what bodybuilders expect of it, the drug is reasonably mild when no aromatizing steroids are present. I consider its potency approximately comparable to Dianabol. It is not unusual for a first time user to do quite well on an oxymetholone-only cycle, but more advanced users will want

to stack with another steroid. Typical use is 50-150 mg/day, which should be divided into several doses per day.

Because oxymetholone is 17-alkylated, it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle, rather than in the last few weeks.

Trivial name Oxymetholone

Systematic name 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-

(hydroxymethylene)-17-methyl-

CAS number 434-07-1

ATC code A14AA05

Merck Index Number 7036

Chemical formula C21H32O3

Molecular weight 332.477 g/mol

Bioavailability 95%

Metabolism Hepatic

Elimination half-life 9 hours

Excretion Urinary: 95%

Pregnancy category X

Routes of administration Oral
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Information About Steroids By Shrenksonlinepharma

Like methandrostenolone (Dianabol), oxymetholone does not bind well to the androgen receptor (AR), and most of the anabolism it provides is via non-AR-mediated effects. It is therefore a Class II steroid and is best stacked with a Class I steroid. The drug appears to give the same benefits as dianabol. Unlike Dianabol, however, it seems that oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of stanozolol (Winstrol), which is anti-progestagenic. This

progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan, oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast, with testosterone it is a very harsh drug.

Oxymetholone does not convert to estrogen, and thus antiestrogens are not required if no aromatizable AAS are being used. However, in concert with aromatizing drugs, oxymetholone is notorious for worsening “estrogenic” symptoms, possibly by producing progestagenic symptoms which the bodybuilder

confuses as estrogenic, or by altering estrogen metabolism, or by upregulating aromatase.

Compared to what bodybuilders expect of it, the drug is reasonably mild when no aromatizing steroids are present. I consider its potency approximately comparable to Dianabol. It is not unusual for a first time user to do quite well on an oxymetholone-only cycle, but more advanced users will want

to stack with another steroid. Typical use is 50-150 mg/day, which should be divided into several doses per day.

Because oxymetholone is 17-alkylated, it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle, rather than in the last few weeks.

Trivial name Oxymetholone

Systematic name 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-

(hydroxymethylene)-17-methyl-

CAS number 434-07-1

ATC code A14AA05

Merck Index Number 7036

Chemical formula C21H32O3

Molecular weight 332.477 g/mol

Bioavailability 95%

Metabolism Hepatic

Elimination half-life 9 hours

Excretion Urinary: 95%

Pregnancy category X

Routes of administration Oral
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